Clinical illness
[1]
 with laboratory confirmation
of infection:
•   Isolation of dengue virus from serum,
plasma, leukocytes or autopsy tissue
samples
OR
•   Demonstration of a fourfold or greater
rise or fall in reciprocal Immunoglobulin
G (IgG) or Immunoglobulin M (IgM)
antibody titres to one or more dengue
virus antigens in paired serum samples
OR
•   Demonstration of dengue virus antigen
in autopsy tissue by
immunohistochemistry or
immunofluorescence or in serum samples
by EIA
OR
•   Detection of viral genomic sequences in
autopsy tissue, serum or CSF samples by
PCR.